Improving Lives
with LAAE

Improving Lives
with LAAE

Left atrial appendage exclusion (LAAE) may reduce morbidity and mortality for your Atrial Fibrillation (AF) patients

“AF-related strokes cause unacceptably high levels of death and disability, and the scale of the problem across
Europe is increasing as our population ages.12 ” Concomitant LAAE procedures may play a crucial role in helping to save lives and reduce this burden.2,4,14

Patient benefits: Outcomes15

The results of the LAAOS III, a randomised control trial, show that concomitant LAA exclusion (LAAE) improves outcomes compared with no-LAAE in AF patients.

Results showed a lower risk of ischemic stroke or systemic embolism in atrial fibrillation (AF) patients with left atrial appendage exclusion performed during surgery than without it.

  • 33% relative risk reduction at 3.8 years mean follow-up
  • 42% relative risk reduction after first 30 perioperative days

No significant differences were observed in the incidence of perioperative bleeding, heart failure, or death between the trial groups.

Study overview

  • Prospective, randomized study (blinded)
  • 4,811 patients enrolled
  • Multicenter – 105 centers, 27 countries

Kaplan-Meier analysis of cerebrovascular events and all-cause mortality in 222 patients undergoing LAAE

Prospective data collection (n=222)5 – concomitant LAAE was associated with low levels of mortality, with no cerebrovascular events in 99.1% of patients after a median follow-up of 20 months. The low rate of cerebrovascular events of 0.5 per 100 patient-years compares to a rate of 1.2 per 100 patient-years for a CHAD2DS2 VASc score of 2.

Patient benefits: Choice

Concomitant LAAE is an effective alternative for patients unable or unwilling to take oral anticoagulants2

Discuss LAAE options with the surgical team and help protect your patients

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We’re here to help make the benefits of complete LAA exclusion clear. So, if you have any questions, or need more information, please fill in this form and a physician will get back to you.